Cara Therapeutics, Inc.

4 Stamford Plaza

107 Elm Street, 9th Floor

Stamford, Connecticut 06902


April 26, 2022




U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549


Attn:     Michael Davis



 Request to Withdraw Acceleration Request of Cara Therapeutics, Inc., (the “Company”), dated April 22, 2022 for the Registration Statement on Form S-3 (File No. 333-263165) 


Mr. Davis,


On behalf of the Company, I hereby formally request the withdrawal of the acceleration request of Cara Therapeutics, Inc. with respect to the above referenced registration statement, submitted via Edgar on April 22, 2022.


Thank you for the Staff’s cooperation in connection with this matter.


  Very truly yours,
  Cara Therapeutics, Inc.

/s/ Christopher Posner 

    Christopher Posner
    Chief Executive Officer and Director


cc:       Darren DeStefano, Cooley LLP