Cara Therapeutics, Inc.

4 Stamford Plaza

107 Elm Street, 9th Floor

Stamford, Connecticut 06902


April 22, 2022




U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549


Attn:   Michael Davis
Re:   Cara Therapeutics, Inc.
    Registration Statement on Form S-3 (File No. 333-263165)

Request for Acceleration of Effective Date


  Acceleration Request    
  Requested Date:   April 26, 2022
  Requested Time:   4:00 p.m. Eastern Time


Mr. Davis:


In accordance with Rule 461 under the Securities Act of 1933, as amended, the undersigned registrant (the “Registrant”) hereby requests that the Securities and Exchange Commission take appropriate action to cause the above-referenced Registration Statement on Form S-3 (File No. 333-263165) (the “Registration Statement”) to become effective on April 26, 2022, at 4:00 p.m. Eastern Time, or as soon thereafter as is practicable.


Once the Registration Statement has been declared effective, please orally confirm that event with Darren DeStefano of Cooley LLP, counsel to the Registrant, at (703) 456-8034.


[Signature page follows]




  Very truly yours,
  Cara Therapeutics, Inc.

/s/ Christopher Posner

    Christopher Posner
    Chief Executive Officer and Director



cc: Christopher Posner, Cara Therapeutics, Inc.

Darren DeStefano, Cooley LLP




Signature Page to Company Acceleration Request – S-3